7 Comments
Feb 18Liked by Elliot Hershberg

Enjoyed the research roundup, please do more! Thanks.

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"On February 1st, Intellia Therapeutics published new clinical results for CRISPR editing of the liver to treat hereditary angioedema...So far, patients receiving the editing treatment have experienced a 95% reduction in these attacks."

This is incredibly promising!

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Beautiful article and well written! I still consider genetic editing technologies as a double-edged sword but I truly recognize the pioneering work and the massive contribution to scientific advancement.

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Thank you for the robust and thoughtful post! You are an incredible source to maintain literacy in the field.

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Thank you for the updates. I worked on CRISPRi/a tools in grad school but things are developing so fast these days, it's easy to fall behind the times!

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A platform concept that might work here: lots of always-on geothermal energy (up to 2GB (by 2030s) from volcanic brine at 6000’); that includes a revenue engine (up to 600k/yr tonnes of lithium filtered from geothermal brine) funding/supporting a Groq compute facility hosting MOE AI models hosted by devs/scientists incentivized to add IP to each subnetwork. It’s a lot deeper of course, but I continue to develop this.

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