Human genetics, GWAS, eQTLs, and their relationship
Cool study, thanks for posting! So how large should be the fold change in expression to constitute an eQTL?
Thanks Sasha!
Sample size impacts how small of an effect size will show up, but empirical distributions have ~2.5 log fold change.
A good paper if you're interested: https://doi.org/10.1101%2Fgr.216747.116
Thank you for this very interesting essay! Do you have a reading recommendation for some one who want to understand eQTL better? Thanks again!
Thanks Dudu, glad you enjoyed it!
A classic article on eQTLs (actually Pritchard was an author, whose lab this study came out of): https://doi.org/10.1016/j.tig.2008.06.001
A paper describing the study design of GTEx also provides some good motivation for this type of study: https://doi.org/10.1038/ng.2653
Another great explanatory blog. Keep up the super work.
Cool study, thanks for posting! So how large should be the fold change in expression to constitute an eQTL?
Thanks Sasha!
Sample size impacts how small of an effect size will show up, but empirical distributions have ~2.5 log fold change.
A good paper if you're interested: https://doi.org/10.1101%2Fgr.216747.116
Thank you for this very interesting essay! Do you have a reading recommendation for some one who want to understand eQTL better? Thanks again!
Thanks Dudu, glad you enjoyed it!
A classic article on eQTLs (actually Pritchard was an author, whose lab this study came out of): https://doi.org/10.1016/j.tig.2008.06.001
A paper describing the study design of GTEx also provides some good motivation for this type of study: https://doi.org/10.1038/ng.2653
Another great explanatory blog. Keep up the super work.