Welcome to The Century of Biology 🧬
If the 20th century was the century of physics, the 21st century will be the century of biology. While combustion, electricity and nuclear power defined scientific advance in the last century, the new biology of genome research—which will provide the complete genetic blueprint of a species, including the human species—will define the next.
- Craig Venter and Daniel Cohen, Fall 2004, Paris
What a time to be alive. As a species, we’ve arrived at an unprecedented moment in Evolution. We can now read, write, and edit DNA—the source code of all living organisms. Advances in DNA sequencing technology have outpaced Moore’s Law, becoming the “broadly enabling microscope” of the 21st century. DNA synthesis costs have also exponentially decreased. CRISPR has transformed gene editing from a bespoke, error-prone, and laborious process into a programmable task routinely carried out by graduate students around the world.
If Moore’s Law gave birth to the Internet and reordered society, what will come of this exponential progress in our ability to understand and engineer life?
I don’t know the answer, but I’ve dedicated my life to accelerating this biotechnological revolution in pursuit of a beautiful and abundant future. We have a unique opportunity to use these tools to make our bodies, our societies, and our planet healthier. This newsletter is an attempt to distill my learnings from the frontier of biology into coherent and useful essays.
My name is Elliot Hershberg, and I’m a scientist, writer, and investor. I’ve spent eight years working on the frontier of the life sciences. I’m trained as both a biologist and a computer scientist. I’ve spent many hours at the lab bench, and have also worked as a software engineer building tools for genome scientists.
Currently, I’m a PhD student in the Department of Genetics at Stanford. My primary focus is using my software background to build beautiful tools that give biologists new superpowers. I also invest in biotechnology. I was a Bio-IT Fellow at 8VC, and now work as the Biotech Partner at Not Boring Capital with. We back ambitious scientific founders, and help them tell their stories.
“The mistake people make is thinking the story is just about marketing. No, the story is the strategy. If you make your story better you make the strategy better.”
- Ben Horowitz (a16z)
The essays I write primarily come in three flavors:
I want to explain important scientific and technologic advances as they happen. To do this, I’ll continue to share short essays about the bioRxiv preprints I’m the most excited about. I write about preprints because there is often a delay of months to years before important work finally makes it into journals. I find that it also keeps me honest about developing good scientific taste, because I can’t lean on the opinion of the editors at Cell, Nature, and Science. Here’s an example:
I’ll also share some of my own work on new software tools and prototypes, like I did here:
Incredible businesses are being built on top of the emerging technology stack that I focus on. I also share some of these stories through in-depth analysis of companies, and broader strategy writing:
Writing about science and companies involves explaining what is happening. This is important, but I’m also interested in a more fundamental question: why should we pursue biotechnology in the first place?
Contrary to the various flavors of doom and gloom in the current zeitgeist—political progress is hopeless, climate change will kill us, AI will turn us into gray goo—I have a deep conviction that a beautiful biotic future is possible if we steer in the right direction. I feel a responsibility to convey this worldview to others.
My longer term ambition is to develop a philosophy outlining why it is a moral and aesthetic imperative to pursue biotechnology. This essay is a first step in that direction:
I hope that you enjoy this newsletter, and that you decide to join me in this journey. My intention is for this newsletter to always be free. If you’re looking for a way to support my work, consider sharing The Century of Biology with somebody that you think would enjoy it: